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are allergic to sildenafil, as contained in VIAGRA and Revatio®, or any in the elements in VIAGRAEffects of Other Medications on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (main route) and CYP2C9 (small route). Consequently, inhibitors of such isoenzymes may possibly minimize sildenafil clearance and inducers of such isoenzymes